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Multiple Choice

According to the Hodgkin lymphoma pathophysiology provided, which cell types proliferate?

In Hodgkin lymphoma, a small number of malignant Reed-Sternberg cells (derived from B lymphocytes) sit among a broad reactive inflammatory background. These RS cells secrete cytokines and chemokines that recruit and stimulate other immune cells to accumulate in the affected lymph node. So, the proliferating cells in the tumor environment include lymphocytes, eosinophils, neutrophils, and plasma cells. This reflects the inflammatory milieu driven by RS cells, not a clonal expansion of those immune cells themselves. The other statements relate to treatment approaches or disease spread rather than the cellular makeup of the tumor microenvironment.

In Hodgkin lymphoma, a small number of malignant Reed-Sternberg cells (derived from B lymphocytes) sit among a broad reactive inflammatory background. These RS cells secrete cytokines and chemokines that recruit and stimulate other immune cells to accumulate in the affected lymph node. So, the proliferating cells in the tumor environment include lymphocytes, eosinophils, neutrophils, and plasma cells. This reflects the inflammatory milieu driven by RS cells, not a clonal expansion of those immune cells themselves. The other statements relate to treatment approaches or disease spread rather than the cellular makeup of the tumor microenvironment.