Celecoxib (Celebrex) is best described as which type of inhibitor?

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Multiple Choice

Celecoxib (Celebrex) is best described as which type of inhibitor?

Celecoxib is best described as a selective COX-2 inhibitor. It specifically targets the cyclooxygenase-2 enzyme, which is induced at sites of inflammation, to reduce production of pro-inflammatory prostaglandins. By sparing cyclooxygenase-1, which supports gastric mucosal protection and platelet function, it tends to cause fewer GI side effects compared with nonselective NSAIDs that inhibit both COX-1 and COX-2. It is not acetaminophen, which has a different mechanism and is not a classical COX inhibitor in peripheral tissues. While selective COX-2 inhibition reduces GI risk, it carries considerations for cardiovascular safety that clinicians monitor.

Celecoxib is best described as a selective COX-2 inhibitor. It specifically targets the cyclooxygenase-2 enzyme, which is induced at sites of inflammation, to reduce production of pro-inflammatory prostaglandins. By sparing cyclooxygenase-1, which supports gastric mucosal protection and platelet function, it tends to cause fewer GI side effects compared with nonselective NSAIDs that inhibit both COX-1 and COX-2. It is not acetaminophen, which has a different mechanism and is not a classical COX inhibitor in peripheral tissues. While selective COX-2 inhibition reduces GI risk, it carries considerations for cardiovascular safety that clinicians monitor.

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