Celecoxib should not be prescribed to patients with a history of which condition due to increased risk of heart attack?

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Multiple Choice

Celecoxib should not be prescribed to patients with a history of which condition due to increased risk of heart attack?

The key idea is that celecoxib, a COX-2–selective NSAID, carries an increased risk of cardiovascular events, including heart attack, particularly in patients with a history of cardiovascular disease or risk factors. COX-2 inhibitors reduce prostacyclin (a protective, vasodilatory, antithrombotic prostaglandin) more than they affect thromboxane A2 (which promotes platelet activity). This shifts the balance toward a pro-thrombotic state, raising the risk of myocardial infarction and other cardiovascular events. Because of this, celecoxib should be avoided in patients with a history of cardiovascular conditions. In contrast, a history of glaucoma or asthma isn’t the primary reason for avoiding celecoxib based on heart-attack risk, and while peptic ulcer disease involves GI considerations with NSAIDs, it does not address the specific increased risk of heart attack that celecoxib poses in those with cardiovascular disease.

The key idea is that celecoxib, a COX-2–selective NSAID, carries an increased risk of cardiovascular events, including heart attack, particularly in patients with a history of cardiovascular disease or risk factors. COX-2 inhibitors reduce prostacyclin (a protective, vasodilatory, antithrombotic prostaglandin) more than they affect thromboxane A2 (which promotes platelet activity). This shifts the balance toward a pro-thrombotic state, raising the risk of myocardial infarction and other cardiovascular events. Because of this, celecoxib should be avoided in patients with a history of cardiovascular conditions.

In contrast, a history of glaucoma or asthma isn’t the primary reason for avoiding celecoxib based on heart-attack risk, and while peptic ulcer disease involves GI considerations with NSAIDs, it does not address the specific increased risk of heart attack that celecoxib poses in those with cardiovascular disease.

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