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Multiple Choice

For women aged 30-65, Pap smear with cytology plus HPV is performed every how many years?

Co-testing with Pap cytology and high-risk HPV testing is more sensitive than cytology alone, so if both tests are negative in women aged 30–65 and prior screening has been adequate, the risk of developing cervical precancer or cancer in the near term is very low. That safety data supports repeating screening every five years rather than more often. If screening were done with cytology alone, the interval would be shorter (about every three years) because cytology alone misses more lesions. The five-year interval applies specifically to the co-testing approach with negative results and adequate prior screening.

Co-testing with Pap cytology and high-risk HPV testing is more sensitive than cytology alone, so if both tests are negative in women aged 30–65 and prior screening has been adequate, the risk of developing cervical precancer or cancer in the near term is very low. That safety data supports repeating screening every five years rather than more often. If screening were done with cytology alone, the interval would be shorter (about every three years) because cytology alone misses more lesions. The five-year interval applies specifically to the co-testing approach with negative results and adequate prior screening.