In chronic hepatitis B infection, which serologic marker corresponds to exposure/immunity?

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Multiple Choice

In chronic hepatitis B infection, which serologic marker corresponds to exposure/immunity?

In hepatitis B serology, different markers tell you about infection status and immune history. IgG against the core antigen (anti-HBc IgG) persists after exposure and reflects prior contact with HBV, signaling the immune system has encountered the virus and may be involved in the chronic immune response. In chronic HBV, you typically see HBsAg positive and anti-HBc IgG positive, while anti-HBs is usually absent, so IgG anti-HBc serves as the marker of prior exposure and ongoing immune interaction. HBsAg indicates current infection, not just exposure. Anti-HBe relates to infectivity status, not immunity. IgM indicates acute infection, not long-term exposure or immunity.

In hepatitis B serology, different markers tell you about infection status and immune history. IgG against the core antigen (anti-HBc IgG) persists after exposure and reflects prior contact with HBV, signaling the immune system has encountered the virus and may be involved in the chronic immune response. In chronic HBV, you typically see HBsAg positive and anti-HBc IgG positive, while anti-HBs is usually absent, so IgG anti-HBc serves as the marker of prior exposure and ongoing immune interaction.

HBsAg indicates current infection, not just exposure. Anti-HBe relates to infectivity status, not immunity. IgM indicates acute infection, not long-term exposure or immunity.

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