Methotrexate is commonly used to treat which condition?

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Multiple Choice

Methotrexate is commonly used to treat which condition?

Methotrexate is a disease-modifying antirheumatic drug commonly used as first-line long-term therapy for rheumatoid arthritis. In low doses, it dampens synovial inflammation and slows joint damage by mechanisms that include increased adenosine which suppresses inflammatory signaling, and by reducing immune cell proliferation. This makes it effective at reducing pain, swelling, and radiographic progression in RA. The other conditions listed are not typically treated with methotrexate as a primary therapy. Gout is managed with NSAIDs, colchicine, or urate-lowering drugs; osteoarthritis focuses on analgesics and lifestyle measures with limited anti-inflammatory disease-modifying options; ankylosing spondylitis is mainly treated with NSAIDs and, for axial disease, biologics like TNF inhibitors, with MTX offering limited benefit. Thus, rheumatoid arthritis is the best answer.

Methotrexate is a disease-modifying antirheumatic drug commonly used as first-line long-term therapy for rheumatoid arthritis. In low doses, it dampens synovial inflammation and slows joint damage by mechanisms that include increased adenosine which suppresses inflammatory signaling, and by reducing immune cell proliferation. This makes it effective at reducing pain, swelling, and radiographic progression in RA.

The other conditions listed are not typically treated with methotrexate as a primary therapy. Gout is managed with NSAIDs, colchicine, or urate-lowering drugs; osteoarthritis focuses on analgesics and lifestyle measures with limited anti-inflammatory disease-modifying options; ankylosing spondylitis is mainly treated with NSAIDs and, for axial disease, biologics like TNF inhibitors, with MTX offering limited benefit. Thus, rheumatoid arthritis is the best answer.

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