Parkinson's disease pathophysiology involves deficiency of which neurotransmitter?

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Multiple Choice

Parkinson's disease pathophysiology involves deficiency of which neurotransmitter?

Parkinson's disease pathophysiology centers on loss of dopaminergic neurons in the substantia nigra, leading to reduced dopamine in the nigrostriatal pathway. This dopamine deficit shifts the balance toward cholinergic activity in the striatum, producing the hallmark motor features such as bradykinesia, resting tremor, and rigidity. While other neurotransmitter systems participate in basal ganglia circuits, dopamine deficiency is the defining deficit.

Parkinson's disease pathophysiology centers on loss of dopaminergic neurons in the substantia nigra, leading to reduced dopamine in the nigrostriatal pathway. This dopamine deficit shifts the balance toward cholinergic activity in the striatum, producing the hallmark motor features such as bradykinesia, resting tremor, and rigidity. While other neurotransmitter systems participate in basal ganglia circuits, dopamine deficiency is the defining deficit.

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