Which combination of tests constitutes the typical diagnostic workup for lymphoma?

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Lymphoma diagnosis and staging rely on tissue confirmation plus studies that show how far the disease has spread. The best answer includes a tissue biopsy with histopathology to definitively diagnose lymphoma and identify the subtype, which is essential for guiding therapy. In addition, imaging and basic labs are used to stage disease and assess overall status. Imaging with CT of the abdomen/pelvis and chest X-ray (with appropriate views), plus ultrasound and MRI as needed, helps locate enlarged lymph nodes and assess potential extranodal involvement, informing stage and biopsy planning. A CBC with differential provides baseline blood counts and can reveal anemia, leukocytosis, or thrombocytopenia that affect treatment decisions. While bone marrow biopsy can be part of staging for some lymphomas to detect marrow involvement, the combination above represents a comprehensive initial workup, whereas the other options miss either the essential tissue diagnosis or relevant staging information.