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Multiple Choice

Which feature is characteristic of Hodgkin's lymphoma?

Hodgkin lymphoma tends to spread in an orderly, contiguous fashion from one lymph node group to the next along the lymphatic pathways. This often starts with painless cervical (neck) lymphadenopathy and then extends predictably to adjacent nodal regions, usually above the diaphragm. This pattern—single-region involvement at presentation with orderly progression to neighboring groups—is a classic feature that helps distinguish Hodgkin lymphoma from many other lymphomas, which may spread more diffusely or non-contiguously. In contrast, Auer rods in leukemic blasts point to acute myeloid leukemia, Bence Jones proteins in urine point to plasma cell disorders like multiple myeloma, and diffuse abdominal pain is a nonspecific symptom not characteristic of Hodgkin lymphoma.

Hodgkin lymphoma tends to spread in an orderly, contiguous fashion from one lymph node group to the next along the lymphatic pathways. This often starts with painless cervical (neck) lymphadenopathy and then extends predictably to adjacent nodal regions, usually above the diaphragm. This pattern—single-region involvement at presentation with orderly progression to neighboring groups—is a classic feature that helps distinguish Hodgkin lymphoma from many other lymphomas, which may spread more diffusely or non-contiguously.

In contrast, Auer rods in leukemic blasts point to acute myeloid leukemia, Bence Jones proteins in urine point to plasma cell disorders like multiple myeloma, and diffuse abdominal pain is a nonspecific symptom not characteristic of Hodgkin lymphoma.