Which finding may indicate organ rejection?

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Acute organ rejection is an immune-driven attack on the transplanted organ, so systemic inflammatory symptoms often surface as an early clue. Fever with malaise (the flu-like presentation) reflects this heightened immune activity targeting the graft, making it the most likely sign of rejection among the options. In solid-organ transplantation, you’d also look for changes in graft function with organ-specific tests (for example, rising creatinine for kidney, abnormal liver enzymes for liver, or new heart function issues), but the presence of fever and vomiting aligns most directly with an acute rejection process.

Rash and pruritus can result from drug reactions or skin conditions, not a classic sign of solid organ rejection. Chronic fatigue is nonspecific and can stem from many post-transplant factors. Weight gain might indicate fluid retention or other complications rather than rejection itself. If rejection is suspected, prompt evaluation of graft function and, when indicated, biopsy are important steps to confirm and guide treatment.