Which histologic finding is diagnostic of Hodgkin's lymphoma?

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Reed-Sternberg cells are the hallmark histologic finding for classical Hodgkin lymphoma. These are large B cells that typically have two mirror-image nuclei with prominent nucleoli, giving an owl’s-eye appearance under the microscope. Seeing these cells in a lymph node biopsy, within the appropriate clinical setting, is diagnostic for Hodgkin lymphoma.

Other findings listed belong to different diseases: Auer rods are needle-like inclusions seen in myeloid leukemias; Call-Exner bodies are small round spaces found in granulosa cell tumors of the ovary; spherocytes are red blood cells seen in hereditary spherocytosis or autoimmune hemolytic anemia.