Which item is NOT listed as a predisposing factor for systemic lupus erythematosus in the provided material?

• A. Vitamin C deficiency
• B. Previous infection with mononucleosis
• C. Genetics
• D. Gender

Answer: (A)

Fears of developing systemic lupus erythematosus are tied to factors that influence immune system regulation and autoimmune risk. In the material, genetics and gender are classic contributors—genetic susceptibility runs in families, and the disease is much more common in females, suggesting hormonal or other sex-linked influences. A prior infection with mononucleosis, linked to Epstein-Barr virus, is also noted as a potential trigger that can provoke autoimmune responses in susceptible individuals.

Vitamin C deficiency, while it causes scurvy and can impair various immune functions, is not presented as a predisposing factor for lupus in the material. It does not reflect the autoimmune, genetic, or infection-trigger mechanisms associated with lupus risk, which is why it’s the correct choice for something not listed as a predisposing factor.