Which sign can indicate hepatotoxicity?

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Hepatotoxicity can lead to brain dysfunction through hepatic encephalopathy, so cognitive changes are an important sign. When the liver is damaged, it can’t detoxify toxins like ammonia effectively, causing confusion, agitation, and delirium. This alteration in mental status is a classic and early indication of significant liver dysfunction from toxicity or failure.

Weight gain can occur with fluid retention in advanced liver disease, but it’s not specific to hepatotoxicity. Cough and hypothyroidism aren’t direct signs of liver injury.